E. Blaise DePaolo earned her MFA in Ceramic Sculpture with a minor in Glass from the Rochester Institute of Technology, School of American Craft, in 1997. She did her undergraduate work at the Evergreen State College in Olympia, Washington. DePaolo's travels to Mexico and Guatemala, touring Mayan ruin sites, have been a defining influence on her work. She has exhibited nationally, has work in numerous public and private collections and is a community-artist. She has designed and delivered art programs for diverse populations throughout Baltimore and the State of Maryland. Recent public art installations include: Health Care for the Homeless, Loyola University's Center for Civic Engagement and Social Justice, League for the People with Disabilities, and the Grow Justice Mural for the Peninsula Jewish Community Center in Foster City, California.

DePaolo has been on the visual art faculty of Morgan State University since 2002. She began her career at Morgan as an adjunct and is now the Associate Professor of Sculpture. Her time at Morgan has inspired a passion for African American Art and culture.