Education:

Post-Doc University of Maryland Baltimore County, 2007-2013
Ph.D. University of Turku (Finland), 2007
M.Sc. University of Turku (Finland), 1996

Research Interests:
Nucleic acids chemistry, chemical toxicology, environmental chemistry, natural products synthesis, carbohydrate chemistry, and teaching strategies development. The main interest is to study properties of chemical contaminants and their biological effects on DNA, from DNA synthesis to analytical analysis and applications.

Selected Publications:

• Koissi N., Fishbein C.J.: (2013) Trapping of a Cross-link formed by a major purine adduct of a metabolite of the carcinogen N-Nitrosomorpholine by Inorganic and biological reductants. Chem. Res. Toxicol. 26, 732.
• Koissi N., Shah N., Ginevan B., Eck W.D., Roebuck B.D., Fishbein C.J.: (2012) A lactone metabolite common to the carcinogens dioxane, diethylene glycol and N-nitrosomorpholine: aqueous chemistry and failure to detect liver cancer induction or promotion in the F344 rat. Chem. Res. Toxicol. 25, 1022.
• Koissi N., Lönnberg H.: (2007) Synthesis of modified nucleosides for incorporation of formyletheno and carboxyetheno adducts of adenine nucleosides into oligonucleotides. Nucleosides, Nucleotides & Nucleic Acids 26, 1203.
• Ruohola A-M., Koissi N., Andersson S, Lepistö I., Neuvonen K., Mikkola S., Lönnberg H.: (2004) Reaction of 9-substituted guanines with bromomalonaldehyde in aqueous solution predominantly yield glyoxal derived adducts. Org. Biomol. Chem. 2, 1943.
• Neuvonen K., Koissi N., Lönnberg H.: (2002) Condensation of triformylmethane with adenosine: novel cyclic adducts derived from 1,3-dicarbonyl compounds. J. Chem. Soc., Perkin Trans. 2. 173.
• Mikkola S., Koissi N., Ketomäki K., Rauvala S., Neuvonen K., Lönnberg H.: (2000) Reactions of adenosine with bromo- and chloromalonaldehydes in aqueous solution: kinetics and mechanism. Eur. J. Org. Chem. 12, 2315