Research Interests:

• New drug discovery
• Natural products
• Quality analysis
• Botanical drugs
• Medicinal plants
• Dietary supplements

Dr. Peng's research interests focus on the identification and analysis of bioactive components from natural resources, including plants, fungi, microbes, and marine invertebrates. His research program explores natural products in three major fields: (1) Discovery of new drug leads from natural resources for the treatment of human diseases such as cancer and infectious diseases, using bioassay-guided isolation, structure elucidation, and chemical optimization; (2) Investigation of the scientific basis of dietary supplements and herb medicines, through studying the bioactive components and pharmacology, and establishing comprehensive analytical methods for better control the quality of them; (3) Development of new botanical drugs.

Google Scholar:  https://scholar.google.com/citations?user=owO1V04AAAAJ&hl=en

Selected Publications (total 103, h-index 28, i10-index 51, citations 3070):

• Susan L. Mooberry, Jiangnan Peng, April Risinger, Jing Li. New taccalonolide microtubule stabilizers. PCT/US2017/066779, US 2019/10501490.
• Jiangnan Peng, Sharadrao Patil, David A. Keire, Kang Chen. Chemical Structure and Composition of Major Glycans Covalently Linked to Therapeutic Monoclonal Antibodies by Middle-Down Nuclear Magnetic Resonance. Analytical Chemistry, 2018, 90 (18), 11016-11024. DOI: 10.1021/acs.analchem.8b02637
• Li Shen, Li Zhu, Qingwei Tan, Dan Wan, Ju Xie, Jiangnan Peng. New cytotoxic trichothecene macrolide epimers from an endophytic Myrothecium roridum IFB-E012. J. Antibiotics. 2016, 69, 652-655.
• Jiangnan Peng, April L. Risinger, Jing Li, and Susan L. Mooberry. Synthetic reactions with rare taccalonolides reveal the value of C-22,23 epoxidation for microtubule stabilizing potency. J. Med. Chem. 2014, 57, 6141-6149.
• Jing Li, April L. Risinger, Jiangnan Peng, Zhongliang Chen, Lihong Hu, Susan L. Mooberry. Potent taccalonolides, AF and AJ, inform significant structure activity relationships and tubulin as the binding site of these microtubule stabilizers. J. Am. Chem. Soc. 2011, 133, 19064-19067.
• Jiangnan Peng, April L. Risinger, Gary A. Fest, Evelyn M. Jackson, Gregory Helms, Lisa A. Polin, Susan L. Mooberry. Identification and biological activities of new taccalonolide microtubule stabilizers. J. Med. Chem. 2011, 54, 6117-6124.
• Jiangnan Peng, Allen R. Place, Wesley Yoshida, Clemens Anklin, Mark T. Hamann. Structure and absolute configuration of karlotoxin, an ichthyotoxin from the marine dinoflagellate Karlodinium veneficum. J. Am. Chem. Soc., 2010, 132, 3277-3279.
• Jiangnan Peng, Sucheta Kudrimoti, Hari K. Pennaka, Yeun-Mun Choo, Karumanchi V. Rao, Babu L. Tekwani, Alejandro M.S. Mayer, Melissa R. Jacob, Lan Chun Tu, Jurg Gertsch, Mark T. Hamann. Structure activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections. J. Med. Chem., 2010, 53, 61-76.
• Jiangnan Peng, Jinfeng Hu, Abul B. Kazi, Ze. Li, Mitchell Avery, Olivier Peraud, Russell T. Hill, Scott G. Franzblau, Fangqiu Zhang, Raymond F. Schinazi, Susan S. Wirtz, Phillip Tharnish, Michelle Kelly, Subagus Wahyuono, Mark T. Hamann. Manadomanzamines A and B, a novel alkaloid ring system with potent activity against mycobacteria and HIV-1. J. Am. Chem. Soc. 2003, 125, 13382-13386.
• Jiangnan Peng, Mitchell A. Avery, Mark T. Hamann. Cyanthiwigin AC and AD, two novel diterpene skeletons from the Jamaican sponge Myrmekioderma styx. Org. Lett. 2003, 5, 4575-4578