Education:

Ph.D. Pharmacology, The Pennsylvania State University College of Medicine, 1994
B.S. Biology, The College of New Jersey (formerly Trenton State College), 1983

Research Interests:

Monosodium urate de-crystallization with gold nanoparticles and low-power microwave heat in the MSUC-induced arthritic gout rat model.

Current Research:

Dr. McLemore's new research project will focus on developing an alternative gout treatment using monosodium urate de-crystallization with gold nanoparticles (AuNP) and low-power microwave heat (l-p MWH) in gouty rats. First, we will establish a monosodium urate crystal (MSUC)-induced arthritic gout rat model via injecting MSUCs into ankle joint tissues, visualizing MSUCs via optical imaging, characterizing the size and number of MSUCs, and assessing hyperalgesia and inflammation. Next, we will optimize the power and exposure time for the safe use of l-p MWH and establish the optimal AuNP size to use to assess the efficacy of our gout treatment. We hypothesize that in the gouty rat our alternative gout treatment, consisting of l-p MWH-accelerated AuNP ("nano-bullets"), is a more efficacious treatment than standard colchicine therapy (SCT). Finally, we will determine the efficacy of our gout treatment versus SCT via visualizing MSUC via optical imaging, characterizing MSUC size and number, and assessing hyperalgesia and inflammation after both treatments.

Courses Taught:

• BIOL 101, Introductory Biology I for Non-Science Majors
• BIOL 102, Introductory Biology II for Non-Science Majors

Selected Publications:

• Gauda EB, McLemore GL. Premature birth, homeostatic plasticity and respiratory consequences of inflammation. Respir Physiol Neurobiol. 2020 Mar;274:103337. doi: 10.1016/j.resp.2019.103337. Epub 2019 Nov 13. PMID: 31733340.

• Boone-Kukoyi Z, Moody K, Nwawulu C, Ariori R, Ajifa H, Guy JA, Lansiquot C, Ozturk B, McLemore GL, Bonyi E, Aslan K. Metal-Assisted and Microwave- Accelerated Decrystallization of Pseudo-Tophus in Synthetic Human Joint Models. ACS Omega. 2019 Feb 28;4(2):4417-4428. doi: 10.1021/acsomega.8b03497. PMID: 30868110; PMCID: PMC6407899.

• McLemore GL, Toker S, Boone-Kukoyi Z, Ajifa H, Lansiquot C, Nwawulu C, Onyedum S, Kioko BM, Aslan K. Microwave Heating of Crystals with Gold Nanoparticles and Synovial Fluid under Synthetic Skin Patches. ACS Omega. 2017 Sep 30;2(9):5992-6002. doi: 10.1021/acsomega.7b00816. Epub 2017 Sep 20. PMID: 28983527; PMCID: PMC5623947.

• Richardson KA, Hester AK, McLemore GL. Prenatal cannabis exposure - The "first hit" to the endocannabinoid system. Neurotoxicol Teratol. 2016 Nov- Dec;58:5-14. doi: 10.1016/j.ntt.2016.08.003. Epub 2016 Aug 24. Review. PubMed PMID: 27567698.

• McLemore GL, Richardson KA. Data from three prospective longitudinal human cohorts of prenatal marijuana exposure and offspring outcomes from the fetal period through young adulthood. Data Brief. 2016 Oct 18;9:753-757. doi: 10.1016/j.dib.2016.10.005. PMID: 27833935; PMCID: PMC5096595.